This is for people who want a more complete understanding of their genes and health, and for those who have a personal or family history of conditions covered. Color Extended includes all genes currently analyzed by Color. To see a list of genes that can impact medication response, click here.
Color Extended: The most relevant genes for common hereditary cancers
* CDK4: analysis is limited to chr12:g.58145429-58145431 (codon 24). EPCAM: analysis is limited to deletions that minimally encompass the 3’ end of the gene including exons 8 and/or 9. GREM1: analysis is limited to duplications that overlap the upstream regulatory region. MITF: analysis is limited to chr3:g.70014091 (including c.952G>A). PMS2: analysis is limited to exons 1-11. POLD1: analysis is limited to chr19:g.50909713 (including c.1433G>A). POLE: analysis is limited to chr12:g.133250250 (including c.1270C>G).
* APOB: analysis is limited to chr2:g.21229159_21229161 (codon 3527). KCNH2: exon 4 and 14 are not analyzed. KCNQ1: exon 1 is not analyzed. MYBPC3: exon 11 is not analyzed. MYH7: variants of uncertain significance are not reported for exon 27. PRKAG2: exon 5 is not analyzed. TGFBR1: exon 1 is not analyzed.
|Gene||Star alleles and variants analyzed|
|CYP1A2||*1F, *1J, *1K|
|CYP2D6||*2, *3, *4, *4N, *5, *6, *7, *8, *9, *10, *11, *12, *14A, *14B, *15, *17, *19, *29, *35, *36, *41, *xN|
|CYP2C19||*2, *3, *4A, *4B, *10, *17|
|CYP2C9||*2, *3, *4, *5, *6, *8, *11|
|CYP3A5||*3, *6, *7|
|TPMT||*2, *3A, *3C, *4|