Large, diverse populations

Color supports the recruitment and testing of large populations through health systems, enterprises, and other channels. This creates the opportunity to recruit more diverse and under-studied populations than through traditional recruitment efforts.

Streamlined sample collection

Color enables remote submission operations through saliva-based collection kits. Sample collection kits can be mailed to participants’ homes, stocked in clinics, or distributed at large events. Providing a sample takes only a few minutes. Samples are then mailed back to Color’s sequencing lab. Recruitment at population scale, simplified.

Color’s bioinformatics pipeline achieves best-in-class variant calling (for SNVs, indels, and structural variants) and imputation, through extensive use of machine learning and data-driven approaches. Color’s custom software tools and automation workflows allow for scale as well as lab optimizations, while decreasing operational overhead, runtime, and other costs.

Color combines distributed systems engineering with computational biology to run one of the fastest whole-genome bioinformatics pipelines in the industry, allowing it to process up to hundreds of thousands of samples in days, on concurrent nodes.

Not only is Color running a state-of-the-art bioinformatics pipeline, but also advancing the field. Recent publications, posters, and blog posts:

• A machine learning model to determine the accuracy of variant calls in capture-based next generation sequencing
• Optimizations in target enrichment and bioinformatics enable sensitive detection of copy number variations in targeted NGS
• Incorporating multiple NGS read features enables detection of transposon insertions across the genome
• How do you set a bioinformatics speed record?
• Building a high-quality, reliable, and efficient bioinformatics pipeline
• Structural Variant Simulator Improves Variant Calling Accuracy in NGS