Learn about hereditary high cholesterol
About 1 in 50 people with high cholesterol are born with Familial Hypercholesterolemia (FH), a hereditary disorder which can impact you and your family.1
What is cholesterol?
Cholesterol is a fat-like substance found in every cell in your body. There are two main types:
LDL (or “bad cholesterol”) can clog your arteries and prevent blood from flowing to and from your heart.
HDL (or “good cholesterol”) removes excess cholesterol from your blood.
Too much LDL can cause coronary heart disease, which can lead to a heart attack or stroke.
FH is a hereditary disorder that causes very high cholesterol levels from an early age
If you have FH, your liver is unable to remove enough LDL, or bad cholesterol, from your blood. This means your LDL level remains high, despite positive lifestyle choices.
FH makes you more likely to get coronary heart disease
Having FH means you’re exposed to high cholesterol from an early age, which make you 22 times more likely to develop coronary heart disease than are those with normal cholesterol and no FH.1
FH can be managed successfully
Your healthcare provider might recommend medication to remove some of the bad cholesterol from your body, along with changes to your diet and lifestyle to protect your heart.
FH is passed down through families
Your results can be informative for your relatives of either gender. If you have FH, there’s a 50% chance that each of your children, siblings, and parents will also have FH. Early identification and treatment can help reduce the risk of coronary heart disease.
Color can help you learn your risk for FH
Testing negative for FH is valuable information
If a relative carries a genetic mutation that causes FH and your results indicate that you don’t have the same mutation, you can be confident that you didn’t inherit it. Healthcare providers refer to this result as a “true negative,” because it indicates that you haven’t inherited the same mutation that is associated with FH in your relatives.
Even if your relatives don’t have an identified mutation, testing negative for mutations on Color’s Hereditary High Cholesterol Test may indicate that you have a reduced chance of having a hereditary predisposition to high cholesterol.
We recommend that you investigate your family history to learn if anyone has FH or has had genetic testing for FH.
What can I do if I have FH?
The FH Foundation
The FH Foundation is a patient-centered non-profit dedicated to research, advocacy, and education of all forms of FH.
National Heart, Lung, and Blood Institute
Provides leadership for a research, training and education program to promote the prevention and treatment of heart, lung, and blood diseases.
American Heart Association
Focused on building healthier lives free of heart disease by promoting heart healthy lifestyle choices, providing accessible education, and funding innovative research.
Color’s lab, team and processes generate results you can trust.
- Color genetics tests have been validated according to ACMG, AMP, and regulatory agencies’ recommendations for molecular clinical tests.
- Our advanced, CAP-accredited and CLIA-certified laboratory uses the newest technology, including 2D barcoded tubes and advanced liquid-handling robots, to ensure the integrity of every result.
- The quality of every sample is checked multiple times as it moves through the sequencing and interpretation process.
- Our Ph.D. and M.D. scientists use state-of-the-art tools to classify variants according to ACMG guidelines.
- A certified medical professional reviews every result before it is released.
- Khera AV, Won HH, Peloso GM, et al. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol. 2016;67(22):2578-89.
- Nordestgaard BG, Chapman MJ, Humphries SE, et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J. 2013;34(45):3478-90a.